Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Digoxin for peak identification European Pharmacopoeia (EP) Reference Standard | 20830-75-5 | MFCD00003674 |
Digoxin for peak identification European Pharmacopoeia (EP) Reference Standard | Mol Wt: 780.94 | 20830-75-5 | MFCD00003674 |
Sigma Aldrich Fine Chemicals Biosciences Metoclopramide European Pharmacopoeia (EP) Reference Standard | 364-62-5 | MFCD00211338 |
Metoclopramide European Pharmacopoeia (EP) Reference Standard | Mol Wt: 299.8 | 364-62-5 | MFCD00211338 |
Sigma Aldrich Fine Chemicals Biosciences Phytomenadione British Pharmacopoeia (BP) Reference Standard | 84-80-0 | MFCD00214063 |
Phytomenadione British Pharmacopoeia (BP) Reference Standard | Mol Wt: 450.7 | 84-80-0 | MFCD00214063 |
Sigma Aldrich Fine Chemicals Biosciences Pancuronium bromide European Pharmacopoeia (EP) Reference Standard | 15500-66-0 | MFCD00079223 |
Pancuronium bromide European Pharmacopoeia (EP) Reference Standard | Mol Wt: 732.67 | 15500-66-0 | MFCD00079223 |
Apexbio Technology LLC Salinomycin 53003-10-4 10mg
Salinomycin is a polyether ionophore antibiotic derived from Streptomyces albus with demonstrated antitumor activities against various cancer cell types It is proposed to function by disrupting multiple signaling pathways including Wnt/ -catenin signaling and interference with ABC drug transport proteins In vitro research on human hepatocellular carcinoma (HCC) cell lines HepG2 SMMC-7721 and BEL-7402 indicates antiproliferative effects with IC50 values of 7 7 M 13 7 M and 10 4 M respectively after 24-hour treatment Studies show that salinomycin induces cell cycle arrest apoptosis via increased Bax/Bcl-2 ratio reduces -catenin expression and elevates intracellular calcium concentrations In vivo assays using orthotopic liver cancer models corroborate its antiproliferative and pro-apoptotic activities suggesting utility in oncology research
Apexbio Technology LLC Colchicine 64-86-8 500mg
Colchicine (CAS 64-86-8) is a small-molecule inhibitor targeting tubulin polymerization It binds directly to tubulin monomers disrupting their polymerization into microtubules (IC50 3 2 M) By preventing microtubule assembly colchicine interferes with spindle formation arresting cells in mitosis at metaphase thereby functioning as a mitotic inhibitor Additionally colchicine demonstrates anti-inflammatory activity by suppressing neutrophil motility and function reducing urate crystal deposition and has been effectively used in animal models of gouty arthritis It is widely utilized in biomedical research to study microtubule dynamics mitosis control and inflammatory pathways
Apexbio Technology LLC Bromfenac sodium hydrate 120638-55-3 10mg
Bromfenac sodium hydrate (CAS 120638-55-3) is an orally active inhibitor of cyclooxygenase enzymes with potent inhibitory activity against both COX-1 and COX-2 isoforms In vitro assays have demonstrated IC50 values of approximately 5 56 nM against COX-1 and 7 45 nM against COX-2 Its mechanism involves blocking prostaglandin synthesis consequently reducing inflammatory mediator levels Bromfenac sodium hydrate is commonly employed in biomedical research addressing ocular inflammation pain and related inflammatory processes
U.S. Pharmacopeia Racepinephrine Hydrochloride, 329-63-5, MFCD00050562, 30mg
Molecular formula C9H13NO3.ClH, Molecular weight 219.67, Melting point/freezing point 311 - 314.6 °F (155 - 157 °C), Synonyms: DL-Adrenaline hydrochloride
Apexbio Technology LLC ONX-0914 (PR-957) 960374-59-8 10mM (in 1mL DMSO)
ONX-0914 (PR-957) is a selective inhibitor targeting the immunoproteasome subunit 5i (LMP7) a proteolytic component involved in antigenic peptide processing for MHC class I presentation By reversibly binding the 5i-specific catalytic pocket ONX-0914 impairs the production of pro-inflammatory cytokines in activated human peripheral blood mononuclear cells (PBMCs) and suppresses IL-17 secretion during Th17 cell differentiation ONX-0914 has been employed experimentally in preclinical models of autoimmune conditions such as arthritis colitis and diabetes Reported IC50 values are approximately 5 15 nM for the 5i subunit demonstrating selective preference over constitutive proteasome subunits
Apexbio Technology LLC ONX-0914 (PR-957) 960374-59-8 100mg
ONX-0914 (PR-957) is a selective inhibitor targeting the immunoproteasome subunit 5i (LMP7) a proteolytic component involved in antigenic peptide processing for MHC class I presentation By reversibly binding the 5i-specific catalytic pocket ONX-0914 impairs the production of pro-inflammatory cytokines in activated human peripheral blood mononuclear cells (PBMCs) and suppresses IL-17 secretion during Th17 cell differentiation ONX-0914 has been employed experimentally in preclinical models of autoimmune conditions such as arthritis colitis and diabetes Reported IC50 values are approximately 5 15 nM for the 5i subunit demonstrating selective preference over constitutive proteasome subunits
n1cc(cn1)-c1ncnc2[nH]ccc12 | 10g | 303335421](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000491939.jpg-250.jpg)
eMolecules 941678-49-5 | Ruxolitinib | Combi-Blocks | MFCD12031592 | 306.373 | C17H18N6 | 98.000 | N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 | 10g | 303335421
Ruxolitinib | Combi-Blocks | 941678-49-5 | MFCD12031592 | 306.373 | C17H18N6 | 98.000 | N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 | 10g | 303335421
Cayman Chemical Montelukast 250mg
A CysLT1 receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor); selective for CysLT1 over CysLT2 receptors (IC50 = >10,000 nM in COS-7 cell membranes expressing the human receptor); inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 69 nmol/kg, p.o.); inhibits ovalbumin-induced airway hyperresponsiveness and increases in the number of total cells and eosinophils in BALF in a mouse model of allergic asthma at 3 and 10 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Gibberellic acid suitable5G
Gibberellic acid is an endogenous plant growth regulator